This has happened in many different applications, FI, N20 & N/A, with different intakes, stock, LS6, Vic's... and fuel systems, return or returnless. The arguments are as follows:
1) #7 is the farthest back and due to block design doesn't have adequate coolant circulation since there are block offs unlike earlier years that had cross overs.
2) Returnless fuel systems can have trash build up in the fuel rails/injectors since there is not an inline filter and no way to return the trash to the tank.
3) The stock intake design doesn't allow for even air distribution, especially in heavily modified applications, which cause #7 to run lean and not show on a wideband.
These are the main arguments or theories. The problem is failure has occured when some of these are not present. For example, someone is running an aftermarket intake or upgraded fuel system and they still lose #7.
Nothing has been absolutely, 100% proven to be the causing factor that I have read. IMO, I think that it's probably a combination of some of the above issues and not just one in particular. In addition, the factory clearances are set up tighter than what you would normally run in a highly modified set up which just adds another possibilty of reason for failure.
If you have never heard of this being an issue, now you have!
