Howdy!
A buddy of mine recently bought, then totalled a 2000 Chevy 1500 with a 5.3 / 4l60e. He rolled it approx 12 times after hitting the ditch, then overcorrecting to get back onto the road. The engine and such all survived the crash, though the body is totally shot (buddy is alright too)
He has graciously offered to let me buy the engine, and all related components off him at a pretty good price, so I am looking into possibly doing a upgrade on my current DD's powerplant next summer once I'm done university. Currently I've got a Vortec 4.3L / NV3500 / NP241 combo in my 96 GMC K1500, and while it gets me around alright, and does get some pretty respectable mileage running around empty, it leaves much to be desired getting onto the highway, or when I toss my quad in the back, and hook the boat up behind to go camping in the summer.
The 2000 5.3 still runs without any trouble, and has very low mileage, approx 50 000 miles (my 96 has 70 000 miles), and I'd be welcome to take the whole engine, and all related electrical.
I've already converted my old 77 Chevy Stepper to TBI, then converted my baby ('80 GMC 3/4 ton 4x4) over to TPI, so I'm not entirely new to EFI, but still have a number of equestions to ask you guys.
First question is related to my standard tranny. I'm aware that the NV3500 should bolt straight up to the engine, as far as the bellhousing goes, but my question is with regards to the flywheel and pressure plate. Will they play with my NV3500's stock clutch disk, and throwout bearing? How about the pilot bearing? Can a guy get one that will work with the NV3500?
Next is with regards to exhaust -- My 4.3L has a good exhaust system on it, 2.5" single with a new cat, and new 02 sensors off both manifolds, and after the cat. Am I going to have to replace the whole setup, or can I make my existing exhaust work? I can get the exhaust off the 2000, but I am not entirely sure how well it will fit my older bodystyle truck.
Third is with regards to instrumentation. Does my NV3500 produce the proper signal for use with the 5.3s ECM etc?
I'd re-work the wiring harness myself, like I did with both the TBI and the TPI conversion, and I'm not concerned about the cooling system, fuel system, or mounting the engine otherwise.
What kind of hidden costs are there that I'm not thinking about? Assuming I spend 1000 on the engine, and all useable components from the 2000, how much do you figure I'd have in it when all was said and done?
Sorry for coming here any asking questions I'm sure you've all heard a million times, but my searching only turned up results for either older, or newer trucks 
Thanks for any help / advice you guys have! All I'm really looking for is to figure out exactly what is involved, and find some good reading material so I can make an educated decision of if I should do the 5.3 swap, or just go with a tried and true Vortec 350.
Russ
EDIT -- Just about forgot! Here are a few pics of my 96!

- Russ
1996 GMC Sierra K1500 - 4.3L NV3500 / NP241 - DD
1980 GMC Sierra Classic K25 - 5.3L NV4500 / NP241 - Project Truck