Just build a 6.0 block, it already has the 4" bore. Going well over .125" over is going to get into some serious cylinder thickness issues (think overheating, distortion, etc).

I heard that Wiseco and JE were made by the same company... if so, I wouldn't want JEs. I have seen a few sets crap out. Diamond or Ross are nice. I'm going to use Venolias.