Chris, it kind of depends on how big of a cam you are gunna go with, what type of cam lobe design, and how stiff of valve springs you are gunna use.
It is known that the DOD lifters ARE weaker when used with Comp's XE-R and LS-K lobes due to their steep ramp rates. Also, anything over .580 lift will put a strain on them. What is the cam size you wanna go with?