As long as you add the air helper springs it should work great. The four inch rear drop without a c-notch puts the axle really close to the frame. Even small loads cause them to bump.
The air bags prevent it from ever hapening without taking away any of the driving characteristics of the springs.
No more trucks, but this is what I used to have. 2000 GMC Sierra, 6.0L-LQ4, Built 4L60, LS6 Cam, The Other Guys Headers, 3 inch exhaust and 7 chamber flowmaster, 43lb injectors, Nelson Tuning, Drop - 3/4 McGaughys Spindles, Bell Tech Shackles & Hangers. Best time 13.59 @ 106