I know I am not that good with hptuners yet, but I have found no one thing is the silver bullet except maybe a pro teaching you step by step. Otherwise it comes down to a little bit of everything. Read a lot, watch whichever videos you can get your hands on(I wouldn't pay for the banish DVDs again although I still own them), use the forums to ask questions, practice using the program as much as you can, and try not to blow anything up.it all comes with time.
ECSB 2kSierra 2wd 4.8L-K&N-HPtuners-Calspeed LT's-Magnaflow-Tahoe20's-HankookRH06
waiting to go in... 3.90s, 214/220cam