Not a direct swap. At all. Mechanically, yes. Electrical, no. From what I've read you'd basically have to run a GMT 900 engine harness PCM & TCM for the 6l80e, running stand alone, along with your trucks factory harness and PCM to run interference between the stand-alone, and your BCM, gauges, A/C etc. Sure it could be done, but I wouldn't want to do it.