safest is run hard line down the frame length, then crimp the end and use flexible hose from hard line to tank and fuel rail. flexible hose being what was said above. size should be 3/8".
return can be 5/16", or 3/8" is fine.
Use quality GM style quick connect ends or name brand compression / crimp fittings.
the best thing you can do is be sure all the fuel line has plenty of room to flex and move between components; make sure no fuel lines are near exhaust parts; make sure no fuel lines are near or resting on anything that is sharp or a 90deg edge (it'll rub right through), you wouldn't believe the stuff we see; be sure you over secure the fuel line with whatever you choose and be sure to remove the feed line going into the fuel rail and purge the entire system to rid it from any contaminants and debris. last thing you want is to finish and have a clogged injector. obviously catch the fuel in a bucket.
that's safe to me