It will work! Try some 80lb injectors and a good fuel pump or a pair of Warbros in the tank. Try the stock cam or a 02 LS6 cam. Waste gate will only need to be bigger if you can't keep the boost down where you need it, one 46mm should be fine. A tight 3K stall would be nice too.
2006 Superior Blue Trailblazer SS AWD, Stock as a rock
Sold: 2002 GMC Sportside Denali front end with a 2002 LS1, FLT level 5, Yank 2600, Trick Turbo, T76, Nelson intercooler, 60LB injectors, Warbro fuel pump, Eaton locker, Magnaflow, 3.42, Nelson Performance Tuning (speed density).
Sold: 1981 GMC LB RC 1500 2002 4.8L 4L60E 12 bolt 3.73 Richmond Lock Right AC PS Nelson Performance tuning