has far as i know, its just of taking the your 5.3 cam out and putting the ls6 cam in.. but i am going to be putting the ls6 cam too in my 5.3l, ill be changin the timing set for a new one, and just putting in new lifters just to be safe, since my truck has 116k on the clock... but no you shouldnt need nothing change but just be safe just change out the parts you know that should be a maybe down the road... i prob put new rockers and rods too if i port my heads... most likely! lol good luck man!

i still have to find a ls6 cam, i have a ls1 tho.... lol.. going to sale that cam since i changed my mind lol... this will always happen