I'm new to this site and far from an expert on racing these trucks, but have been around drag racing a while so here is my

Yes, you want to be at the top of the powerband when going through the traps. But, sometimes the gearing to do this can hurt you off the line. Too much torque multiplication from a low 1st tranny gear and low rear end gear combined with a high TQ motor, could mean trouble getting traction.
Lots of 1/8 mile drag cars switch to 2 speed powerglides and run faster than they did with 3 speeds because of this. They just blow the tires off in 1st gear and immediatly shift into 2nd with the 3 speeds.

I would stick with the 4.10's unless you need the extra gearing to get off the line. But with the low 1st of 4L60's and 550 rwtq I don't think it will be a problem.