I would imagine that any larger than stock size tire will be harder on the drive-train. That being said there are lots of trucks running over-sized tires with little or no trouble. 33's are not that big.
2006 Superior Blue Trailblazer SS AWD, Stock as a rock
Sold: 2002 GMC Sportside Denali front end with a 2002 LS1, FLT level 5, Yank 2600, Trick Turbo, T76, Nelson intercooler, 60LB injectors, Warbro fuel pump, Eaton locker, Magnaflow, 3.42, Nelson Performance Tuning (speed density).
Sold: 1981 GMC LB RC 1500 2002 4.8L 4L60E 12 bolt 3.73 Richmond Lock Right AC PS Nelson Performance tuning