Well you can do a factory SyTy upper and lower intake, but to be honest fully ported they only flow 250 cfm, and can get pretty expensive.
There is a guy over on S-Seriesforum.com, Boosted Thrills that is taking the Holley/Weiand Stealth Ram intake for the SBC and cutting it down to fit the V6, if you go to that forum and to the 6 cylinder section there is a thread with some pics, i recently got the first one finished, and it looks pretty good, and will have a forward facing TB like a TPI or LTI and then you cna fab up the intake tubing, they make the HSR for the later style vortec heads which would be an easy upgrade over the TBI heads, on a stock engine they are worth about 30HP or so.
Heres a link to the thread.
S-SeriesForum.com
I also have a set of brand new 2004 casting vortec V6 heads, that have had the guides machined down to clear .600 lift and had the spring seats machined for larger diameter springs, they stil have stock valve seats 1.94/1.50 and i was gonns have them redone for 2.055/1.60 to go on my Ty, but then the engine broke and i put the project on hold. I really have no need for them now, and ive got almost 600 bucks in them so far, and if your interested ill let you have them for 350 plus shipping.
Also on the EFI control, there is alot of different ways you can go. Aftermarket is nice but expensive, a factory SyTy ecm could be swapped in with alittle wiring, but isnt the easest setup to tune. Another option might be to get an engine harness and computer from a newer 4.3L V6, that way you will have seqential injector control, an LS1 style PCM so if needed you can go to any of the LS1 truck tuners and they should be able to tune it for you, and it wouldnt be that hard at all to have it moddified to be a stand alone and drop right into the truck.
And as luck would have it, i have a complete 2004 4.3L/4L60E engine harness and computer, no AIR injection or EGR as the factory got rid of it in 2003, you can have the trans wiring removed and or converted to run the 700R4 lock up converter, or use an aftermarket TCC control kit, or you can swap in a later model 4L60E r even a 4L80E for ultimate reliability, the PCM will control either. I bought the harness to swap a V8 into my 2K Olds Bravada, but i got totaled in a 5 car pile up on the freeway, and i have no use for it now, i payed 100 bucks plus shipping for it, but ill let it go for 100 shipped. Its probably the cheapest way to get a seqential multiport injection setup on there, and it will work with what ever intake setup you want to run, you can buy a 4 barrel carb intake and convert it to EFI.
EDIT: just seen in the first post your truck is a 93, which means you already have a 4L60E trans, so the engine harness would drop right in, and you can tune the trans with the PCM, just like the newer trucks.
The sky is the limit really.
Hope this info helps you out.