Using 2wd and slicks in a 4x4?

[11 6.2]

i wouldnt run 2 different size tires with the newer 4wd trucks

i run in auto, this allows you to launch with 4 wheels then it becomes 2wd later on

running two different sizes tires will screw the abs up and confuse the truck, not mentioned youll need to readjust the tables in the tune for the smaler tires or the 6l90 wont shift right!!!!

Is this the same with a 2wd with the 6l80? if i put a set of 28" slicks it wont shift the same?