Manual with a solid clutch upgrade is my first choice, but if you do any type of traffic driving or are just plain lazy (which there's nothing wrong with) then a 4l80e with a massive trans cooler is the next choice.
4L60e would burn up pretty quickly if it's stock and used mostly for towing, and the price you put into building it into a monster to handle the towing - you'd be cheaper to have swapped an 80 in the first place. (and the 80 is still a better trans)
I like things with spark plugs...
... oh, and boobs - I like those too.