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I went with a 3/4 drop, springs / shackles / hangers with beltech drop shocks up front an the 275/4/20 and no tire rub and pretty good ride quality. I have alot of buddies that went with spindles and have the same ride as my truck. As far as alighment goes you always take it after a couple of weeks
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on my drop i actually got a brand new belltech off ebay for $250. had lower control arms, with the hangers and shackles in the rear.... i needed to get an alignment afterwards and i would suggest doing the same just for safe keeping...... i dont know how your doing yours but we did mine in an airplane hanger with flor jacks....
tip for the wise..... GET A SPRING COMPRESSOR.... its scary when that thing flys out at you