Originally Posted by
2500Ak
The pcm biases the input from different sensors to tune be when its in open and closed loop. I'd guess that once it goes into closed loop whatever the computer is doing is less compatible with the change in input from its sensors resulting from the cam. Also bigger cam usually means the engine eats more fuel, closed loop is leaner than open loop. You're probably running lean as well. That's just me guess.
Get it custom tuned as has been said before. I went with Justin at BlackBear Preformance, he did a good job.